Screening program of prostate cancer at Tokai University Hospital: characterization of prostate-specific antigen measurement.

نویسندگان

  • Masatoshi Tokunaga
  • Masanori Yasuda
  • Hideshi Miyakita
  • Yoshiaki Kawamura
  • Sunao Shoji
  • Hiroshi Sasaki
  • Takuo Kono
  • Yasuyuki Kobayashi
  • Masanori Shima
  • Yukio Usui
  • Aiichiro Masuda
  • Hidechika Kinoshita
  • Teppei Ogawa
  • Yasuhiko Honma
  • R Yoshiyuki Osamura
  • Toshiro Terachi
چکیده

A total of 67,214 men participated in screening for prostate cancer (PC) using serum prostate-specific antigen (PSA) from April 1996 to March 2003 at Tokai University Hospital. In 3.5% (2330 / 67,214) of the men, an elevated PSA level (> 4.0 ng/ml) was found and 68.1% (1586/2330) of these subjects were examined at our Urological Outpatient Clinic. Re-testing of PSA showed that 8.4% (133/1586) had a normal level. Needle biopsy of the prostate was performed in 45.2% (633/1453) of the remaining men. As a result, 142 PCs were found and the detection rate was 0.2% (142 / 67,214). The age of the patients with PC was over 50 years. During this period, 135 individuals with voiding dysfunction were also diagnosed as having PC. Comparison of the patients detected by screening with those found at the outpatient clinic revealed significant differences of the age (64.8 vs. 71.9 years, p < 0.0001), serum PSA level (14.6 vs. 154.9 ng/ml, p < 0.0001), and clinical stage (p < 0.0001). In conclusion, a health screening program that includes serum PSA testing is useful for detection of PC at an earlier stage and in younger individuals. We recommend that all men aged 50 years or older undergo testing for PSA to detect PC at an early stage.

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عنوان ژورنال:
  • The Tokai journal of experimental and clinical medicine

دوره 30 2  شماره 

صفحات  -

تاریخ انتشار 2005